Lifelong friends Kate, Evie and Charlie are in a rut. Kate spends her days at a middling job and her nights alone or on failed dates. Evie is married with the in-laws from hell, wandering from one charitable cause to the next. Charlie has the girl of her dreams but just can't seem to pull her business (or her act) together. On the eve of Kate's 30th birthday, she agrees to let Evie and Charlie throw her a party. But what's supposed to be a simple celebration becomes a wild who's who of past and present, and things quickly spiral out of control.

An embarrassing video of Anthony surfaces online right before his fifth high school reunion. The Smosh dudes then race to pull down the clip before it blows Anthony's chances of reconnecting with his teen crush Anna.